<p><br></p>
<p style="text-align: center;"><img src="@@PLUGINFILE@@/WEED2.jpg" alt="WEED" width="280" height="180" class="atto_image_button_text-bottom"><img src="@@PLUGINFILE@@/WEED3.jpg" alt="WEED" width="270" height="180" class="img-responsive atto_image_button_text-bottom"><img src="@@PLUGINFILE@@/WEED.jpg" alt="WEED" width="270" height="180" class="img-responsive atto_image_button_text-bottom"><br></p>
<p style="text-align: center;"><br></p>
    <p></p>
    <h3><b>Marijuana/Hashish/THC</b></h3>
    <h5>Marijuana and its sister drugs will Increase frontal alpha amplitude, with increased frontal coherence across the hemispheres, as well as phase synchrony.&nbsp; These findings are reported in chronic exposures.</h5>
    <p>Effects on dampening reaction times in evoked potentials have been noted as well.</p>
    <h4>Anteriorized Alpha in Raw EEG and in the QEEG</h4>
    <p style="text-align: center; "><img src="@@PLUGINFILE@@/anteriorized%20alpha.jpg" alt="Anteriorized alpha" width="500" height="711" class="img-responsive atto_image_button_middle"></p>
    <p style="text-align: center; ">&nbsp;</p>
    <p><br><b style="color: rgb(55, 71, 79); font-family: &quot;Open Sans&quot;; font-size: 1.715rem;">LSD (Lysergic Acid Diethylamide)</b><br></p>
    <h3><span style="font-size: 1rem;"><span><span><span><b><p><b><img src="@@PLUGINFILE@@/LSD%20%281%29.jpg" alt="LSD Effects" width="455" height="300" class="img-responsive atto_image_button_left"></b></p></b></span></span>
        </span>
        </span>
    </h3><span style="font-size: 1rem;">The effect of LSD on the EEG is dependent upon the baseline. If the EEG is normal, there is often a decrease in alpha and an increased in beta frequencies.</span><br><br><span style="font-size: 1rem;">With slower EEG backgrounds, there is an
     increase in alpha and beta activity.</span><br><br><span style="font-size: 1rem;">The low voltage fast EEG phenotype shows little change in
     spectral profile with exposure.<br><span style="font-size: 1rem;"><br>An
     increase in </span><i style="font-size: 1rem;">conditioned inhibition is&nbsp;</i><span style="font-size: 1rem;">seen with lower doses, as well as decreased paroxysmal activity.
     The stimulant effects of this powerful drug may cause convulsions at higher doses, such as in the early government studies. In these studies, </span><i style="font-size: 1rem;">milligram</i><span style="font-size: 1rem;"> doses were supplanted for the </span>
    <i style="font-size: 1rem;">microgram</i><span style="font-size: 1rem;"> recommendations from Switzerland, where the LSD was produced (Sandoz).<br></span></span><h3><b><br></b></h3><p><b><br></b></p><h3><b>PCP, Phencyclidine, or Angel Dust</b>&nbsp;</h3><span style="font-size: 1rem;"><br>PCP causes a marked increase in slow activity, with paroxysmal activity and extreme voltages noted with increased dosage. Convulsions have been reported.</span>
        <p></p>
        <p><span style="font-size: 1rem;"><img src="@@PLUGINFILE@@/pcp.jpg" alt="pcp" width="250" height="195" style="text-align: center; " class="atto_image_button_text-bottom"><img src="@@PLUGINFILE@@/pcp2.jpg" alt="pcp" width="455" height="324" style="text-align: center; " class="img-responsive atto_image_button_right"><br></span></p>
        <p><br></p>
        <h3><b><br></b></h3><h3><b><br></b></h3><h3><br></h3><h3><b>Morphine/Opiates/Heroin</b></h3><span style="font-size: 1rem;">Shortly following administration, there is increased alpha, with slowing of alpha during the euphoric high.&nbsp; With increased dose, there is increased slowing, and like barbiturates, the EEG may go iso-electric. There is an increase in REM sleep noted with opiates.</span>
        <p></p>
        <p style="text-align: center; "><span style="font-size: 1rem;"><img src="@@PLUGINFILE@@/heroin.jpg" alt="Heroin" width="500" height="250" class="img-responsive atto_image_button_middle"><img src="@@PLUGINFILE@@/morphine.jpg" alt="morphine" width="250" height="190" class="img-responsive atto_image_button_middle" style="font-size: 1rem; text-align: center;"><br></span></p>
        <p><br></p>
        <h3><b style="font-size: 1.715rem;">Isoelectric EEG</b><span style="font-size: 1.715rem;">&nbsp;</span></h3>
        <p><span style="font-size: 1rem;"><img src="@@PLUGINFILE@@/isoelectric%20EEG.jpg" alt="Isoelectric EEG" width="500" height="301" class="img-responsive atto_image_button_left">An isoelectric EEG is defined as complete loss of cortical electrical activity with maximal amplification, if sustained for an hour or more under appropriate clinical circumstances, is highly suggestive of cerebral death.<br></span></p>
        <p><span style="font-size: 1rem;"><br></span></p>
        <p><span style="font-size: 1rem;"><br></span></p>
        <p><span style="font-size: 1rem;"><br></span></p>
        <p><span style="font-size: 1rem;"><br></span></p>
        <p><span style="font-size: 1rem;"><br></span></p>
        <p><span style="font-size: 1rem;"><br></span></p>
        <p><br></p>
        <p><span style="font-size: 1rem;"></span></p>
        <h2>Alcohol</h2>

        <p><i><img src="@@PLUGINFILE@@/alcohol.png" alt="Alcohol" width="299" height="200" class="img-responsive atto_image_button_left">Ethanol</i>&nbsp;at higher levels causes slowing to occur, with the depressant effect seen behaviorally.&nbsp; In the low voltage fast type EEG (seen in anxious, nervous and in many chronic alcoholics and their family members), the initial
            alcohol exposure causes the sudden occurrence of alpha. With severe chronic alcoholism, there can be an abnormal pattern&nbsp;<i>of periodic lateralized epileptiform
discharges (PLEDS)</i>&nbsp;seen with altered consciousness. This is not true underlying epilepsy, but rather disappears with the treatment of the alcoholism.
        </p>
        <p><br></p>
        <h4><br></h4><h4><br></h4><h4>Quantitative EEG of a Low Voltage Fast Profile, suggestive of excess GABA-A receptor sites</h4>
        <p style="text-align: center;"><span style="font-size: 1rem;">&nbsp;</span></p>
            <p style="text-align: center;"><br></p>
            <p></p>
            <p style="text-align: center;"><span style="font-size: 1rem;">&nbsp;</span><img src="@@PLUGINFILE@@/low%20voltage%20EEG.png" alt="low voltage" width="499" height="427" class="atto_image_button_middle" style="font-size: 1rem; text-align: center;"></p>
            <p style="text-align: center; "><span style="font-size: 1rem;"><br></span></p>
            <p style="text-align: left;"><span style="font-size: 1rem;">The low voltage fast EEG phenotype is driven by over-arousal. This profile shows a genetic alteration of gene number 4, the gene that controls GABA A receptors, and if you make more receptors than you can saturate, you become over-aroused. This is a prominent variant of people who have alcoholism. Behaviorally, this would show as someone who is over-aroused, perhaps nervous, anxious, or tense. This is someone who will not do well in a highly stressful work environment. But, overall, this it is a normal variant that is present in about 10% of the population. Typically, their alpha is fast and desynchronized.</span></p>
            <h2 style="text-align: left;">Cocaine&nbsp;</h2>
                <p><img src="@@PLUGINFILE@@/coke.jpg" alt="coke" width="400" height="300" class="img-responsive atto_image_button_left" style="text-align: center; "></p>
                <ul type="disc">
                    <li style="text-align: left;">Cocaine decreases <i>synaptic
     reuptake</i>, and amphetamines increase the release of the neurotransmitters in the <i>dopamine/norepinephrine</i> systems in the brain.</li>
                    <li style="text-align: left;"><br></li>
                    <li style="text-align: left;">With lower to moderate doses, there is increased alpha and beta amplitudes. </li>
                    <li style="text-align: left;"><br></li>
                    <li style="text-align: left;">With increased doses, there is a <i>desynchronization</i> of the EEG and faster activity predominates. There is an alpha increase frontally, seen during the euphoric phase of the subjective report. </li>
                    <li style="text-align: left;"><br></li>
                    <li style="text-align: left;">Cocaine is a well-known <i>epileptic potentiator</i>. </li>
                    <li style="text-align: left;"><br></li>
                    <li style="text-align: left;">Chronic abuse causes a “burned out” dopamine system, with delta decreases and slower alpha noted with little improvement even one year later in Prichep’s Phoenix House study.</li>
                </ul>
                <p></p>
                <p style="text-align: left;"><br></p>
                <p></p>
                <p style="text-align: center;"><br></p>
                <p></p>