<p>This area of the brain, Brodmann area 25, is called the subgenual area because it is “below the knee” of the corpus callosum. This area is very deep in the midline cortex and has an very important link to the affect network. It is this area that is considered to be of key intervention to people who have intractable depression. It is rich in serotonin transporters and is influential in many networks. This area governs personality and social behavior, such as moral reasoning and the evaluation of emotional words. It influences the hypothalamus and the brain stem, which are involved in sleep and appetite, as well as the hippocampus, which is essential for memory formation and self-esteem.&nbsp;</p><p>Irregular independent components at the subgenual anterior cingulate affect the function of the brains’ Error Detection and Correction processes.&nbsp; This system which can be stuck in the “off position” as much as it can get stuck “on.” Usually if you are getting a lot of error codes (“that’s wrong,” “did you forget to lock the door,” etc.) a significant marker here could signify an obsessive compulsive or oppositional defiant disorders. The anterior midline holds a model of what is going on in the world at the Subgenual Anterior Cingulate location. When that spot is not working properly, you end up having error codes.&nbsp;</p><p style="text-align: center;"><img src="@@PLUGINFILE@@/ba-25.png" alt="BA 25" width="260" height="383" class="img-responsive atto_image_button_text-bottom"><br></p>